Ferroptosis-IN-23 is an inhibitor of ferroptosis. Ferroptosis-IN-23 exerts a synergistic effect by simultaneously activating Steap4 and glutathione peroxidase 4 (GPX4), thereby maintaining iron metabolism homeostasis. Ferroptosis-IN-23 reverses neuronal ferroptosis and inhibits lipid ROS accumulation in cells. Ferroptosis-IN-23 inhibits ferroptosis in zebrafish, alleviates neuronal apoptosis, ROS accumulation, and dopaminergic neuron damage in a zebrafish model of Parkinsons disease. Ferroptosis-IN-23 can be used for research on Parkinsons disease[1].
Molecular Weight:
370.36
Formula:
C19H18N2O6
Target:
Ferroptosis,Glutathione Peroxidase,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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