Enpp-1-IN-30 (compound 44a) is an orally bioavailable ENPP1 inhibitor with a human IC50 of 13.1 nM. Enpp-1-IN-30 prevents cGAMP degradation, activates the STING pathway. Enpp-1-IN-30 induces cytokine release to enhance innate immune response. Enpp-1-IN-30 exerts antitumor efficacy in syngeneic mouse models. Enpp-1-IN-30 can be used for the research of colon carcinoma[1].
Molecular Weight:
349.38
Formula:
C15H16FN5O2S
Target:
Phosphodiesterase (PDE)
Application Notes:
MCE Product type: Reference compound
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