Anti-inflammatory agent 113 (compound B5) is a Cathepsin L (CTSL) inhibitor and anti-inflammatory agent with a CTSL IC50 of 5.52 µM. Anti-inflammatory agent 113 suppresses CTSL maturation, attenuates NF-kappaB and p38 MAPK signaling pathway activation, and binds stably in CTSLs active site via noncovalent interactions with Asp162, Cys25, and Glu63. Anti-inflammatory agent 113 inhibits pro-inflammatory cytokine (IL-6, IL-8) production, reduces inflammatory cell lung infiltration, and alleviates lung tissue injury. Anti-inflammatory agent 113 can be used for the research of acute lung injury[1].
Molecular Weight:
448.52
Formula:
C27H24N6O
Target:
Cathepsin
Application Notes:
MCE Product type: Reference compound
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