sigma1R/H3R ligand-1 is a dual sigma1R/H3R antagonist with a sigma1R Ki of 8.8 nM and an H3R Ki of 31.2 nM. Through the dual action of simultaneously antagonizing sigma1R and H3R, sigma1R/H3R ligand-1 exhibits potent dose-dependent analgesic activity in mouse models of visceral pain and neuropathic pain. sigma1R/H3R ligand-1 can be used for the research of visceral pain and neuropathic pain[1].
Molecular Weight:
336.45
Formula:
C22H25FN2
Target:
Histamine Receptor,Sigma Receptor
Application Notes:
MCE Product type: Reference compound
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