Topoisomerase I-IN-20 is a Topoisomerase I inhibitor. Topoisomerase I-IN-20 disrupts DNA synthesis and transcription, thereby inhibiting the proliferation and migration of cancer cells. Topoisomerase I-IN-20 induces S-phase cell cycle arrest and mitochondria-mediated Apoptosis in cancer cells, which is characterized by upregulated expression of p53, Bax, caspase-3 and caspase-9, along with downregulated expression of Bcl-2. Topoisomerase I-IN-20 increases intracellular ROS levels. Topoisomerase I-IN-20 is applicable to lung cancer-related research[1].
Molecular Weight:
431.61
Formula:
C23H34FN5S
Target:
Apoptosis,Bcl-2 Family,Caspase,MDM-2/p53,Reactive Oxygen Species (ROS),Topoisomerase
Application Notes:
MCE Product type: Reference compound
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