Anticancer agent 306, CAS [[3043892-01-6]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-181769
Supplier Catalog Number:
HY-181769
Alternative Catalog Number:
MCE-HY-181769-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Anticancer agent 306 is a spiro tetramic acid derivative and a inhibitor of MMP1, MMP7 and PLK1. Anticancer agent 306 exerts antiproliferative activity against H1299, RKO and MCF-7 cells with IC50 values of 19.25 µM, 3.29 µM and 102.36 µM, respectively. Anticancer agent 306 can up-regulate p21 protein and down-regulate CCND1 and CCNB1 proteins to induce cell cycle arrest, regulate the expression of Bcl-2 and Bax to induce cell apoptosis. Anticancer agent 306 can down-regulate MMP1 and MMP7 proteins to inhibit tumor invasion and metastasis. Anticancer agent 306 can be used for the research of lung cancer, colorectal cancer, breast cancer[1].
