ATM-IN-13 (A36) is an orally active, selective ATM kinase inhibitor with a human IC50 of 0.3 nM. ATM-IN-13 blocks the ATM-mediated DNA double-strand break repair signaling pathway, reduces the phosphorylation levels of ATM and p53, and inhibits ATM-dependent DNA damage response. ATM-IN-13 can be used in the research of colorectal cancer[1].
Molecular Weight:
443.58
CAS Number:
[3104731-13-4]
Formula:
C27H33N5O
Target:
ATM/ATR
Application Notes:
MCE Product type: Reference compound
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