DOT1L705 is a PROTAC degrader that targets DOT1L. DOT1L705 recruits the VHL E3 ubiquitin ligase to induce proteasomal degradation of DOT1L. DOT1L705 reduces the viability of leukemia cells. DOT1L705 inhibits H3K79 methylation. DOT1L705 can be used in studies related to MLL-rearranged leukemia[1].
Molecular Weight:
1337.88
CAS Number:
[3050756-34-5]
Formula:
C61H72ClF3N12O13S2
Target:
Histone Methyltransferase,PROTACs
Application Notes:
MCE Product type: Reference compound
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