CSN5-IN-3 (Compound 30) is a CSN5 inhibitor with an IC50 of 0.58 µM. CSN5-IN-3 inhibits the enzymatic activity of CSN5, leading to increased accumulation of NEDD8-Cul1 and promoting the degradation of PD-L1. CSN5-IN-3 downregulates Bcl-2, and upregulates P53 and Cleaved caspase-3. CSN5-IN-3 exhibits anticancer activity against triple-negative breast cancer[1].
Molecular Weight:
441.57
Formula:
C27H31N5O
Target:
Bcl-2 Family,Caspase,MDM-2/p53,PD-1/PD-L1
Application Notes:
MCE Product type: Reference compound
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