TLR7 antagonist-1, CAS [[3104353-70-7]] Preis auf Anfrage

Product Overview

• Article Name: TLR7 antagonist-1, CAS [[3104353-70-7]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-181796
• Supplier Catalog Number: HY-181796
• Alternative Catalog Number: MCE-HY-181796-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

TLR7 antagonist-1 (Compound 44) is an orally active, selective TLR7 antagonist with an IC50 value of 0.3 nM against TLR7. TLR7 antagonist-1 selectively binds to TLR7, inhibits its activation, and downregulates the c-Rel signaling pathway. TLR7 antagonist-1 downregulates the mRNA levels of proinflammatory cytokines IL-1beta, IL-6, and TNF-alpha. TLR7 antagonist-1 alleviates Imiquimod (HY-B0180)-induced psoriasis-like skin lesions. TLR7 antagonist-1 is applicable to research related to psoriasis[1].

Product Properties

• Molecular Weight: 455.90
• CAS Number: [3104353-70-7]
• Formula: C21H25ClF3N5O
• Target: Interleukin Related,Toll-like Receptor (TLR)

Application Notes

• Application Notes: MCE Product type: Reference compound