MRS8288 is a ABCG2 and P-glycoprotein inhibitor, with an IC50 of 0.96 µM against ABCG2 and an IC50 of 1.39 µM against P-glycoprotein. MRS8288 inhibits the ATPase activity of ABCG2 and P-glycoprotein, and suppresses ABCG2-mediated substrate transport. MRS8288 is applicable for cancer research[1].
Molecular Weight:
708.12
Formula:
C36H28ClF2N9O3
Target:
BCRP,P-glycoprotein
Application Notes:
MCE Product type: Reference compound
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