SBP-5147 is an orally active ULK1/ULK2 inhibitor, with an IC50 of 2 nM against ULK1 and an IC50 of 53 nM against ULK2. SBP-5147 inhibits the phosphorylation of Beclin-1 and Vps34, reduces autophagy flux, downregulates the expression of ATG13 and ATG101, upregulates the expression of MHC-I, induces caspase-dependent apoptosis, and decreases the viability of non-small cell lung cancer cells. SBP-5147 is applicable to research related to non-small cell lung cancer[1][2].
Molecular Weight:
349.35
CAS Number:
[1884222-37-0]
Formula:
C17H18F3N5
Target:
Apoptosis,Autophagy,Beclin1,Caspase,MHC,ULK
Application Notes:
MCE Product type: Reference compound
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