Topoisomerase IV-IN-3 is a Staphylococcus aureus Topoisomerase IV inhibitor, DNA gyrase inhibitor and antibacterial agent. Topoisomerase IV-IN-3 has IC50 values of 1.32 µM and 0.48 µM against topoisomerase IV, and 0.88 µM and 0.54 µM against DNA gyrase. Topoisomerase IV-IN-3 inhibits decatenation, ATPase, and supercoiling activities of its target enzymes. Topoisomerase IV-IN-3 exerts antibacterial activity against Gram-positive and Gram-negative bacterial strains. Topoisomerase IV-IN-3 exhibits low cytotoxicity toward human fibroblast cells. Topoisomerase IV-IN-3 can be used for the research of bacterial infections[1].
Molecular Weight:
826.78
Formula:
C34H42N4O18S
Target:
Bacterial,DNA Glycosylase,Topoisomerase
Application Notes:
MCE Product type: Reference compound
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