MMV1581361 is a PfATP4 inhibitor and an orally active, transmission-blocking agent with nanomolar activity against Plasmodium falciparum blood-stage isolates. MMV1581361 disrupts sodium ion (Na+) homeostasis in Plasmodium falciparum. MMV1581361 inhibits male gamete exflagellation, reduces oocyst intensity, and blocks transmission of Plasmodium falciparum. MMV1581361 demonstrates efficacy in the humanized Plasmodium falciparum NOD scid IL2Rgammanull mouse model. MMV1581361 can be used for the research of malaria[1].
Molecular Weight:
434.46
Formula:
C16H17F3N4O3S2
Target:
Na+/K+ ATPase,Parasite
Application Notes:
MCE Product type: Reference compound
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