nTRD22 is an RNA-binding allosteric modulator targeting TDP-43. nTRD22 binds to the N-terminal domain of TDP-43, thereby allosterically regulating the RNA-binding domain of TDP-43 and reducing its RNA-binding ability. nTRD22 decreases the TDP-43 protein level in primary motor neurons. nTRD22 alleviates motor dysfunction in amyotrophic lateral sclerosis models. nTRD22 is applicable to related research on amyotrophic lateral sclerosis[1].
Molecular Weight:
413.39
Purity:
95
CAS Number:
[1065567-62-5]
Formula:
C19H22F3N3O4
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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