BuChE-IN-22 is a pseudo-irreversible butyrylcholinesterase (BuChE) inhibitor, with IC50 values of 4 nM and 157 nM against hBuChE and hAChE, respectively. It also acts as a prodrug of 7-hydroxysertraline. BuChE-IN-22 releases 7-hydroxysertraline during BuChE inhibition. BuChE-IN-22 completely reverses Abeta25-35-induced short-term and long-term memory impairments in a mouse model of Alzheimers disease. BuChE-IN-22 can be used in research related to Alzheimers disease[1].
Molecular Weight:
433.37
Formula:
C23H26Cl2N2O2
Target:
Cholinesterase (ChE),Drug Intermediate
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
