Ki 23057 is a competitive, orally active inhibitor for tyrosine kinase, which inhibits the phosphorylation of K-samII/FGF-R2, VEGF-R1, VEGF-R2, PDGF-Rbeta and c-Kit, with IC50s of 88, 69, 83, 100 and 480 nM. Ki 23057 inhibits the proliferation of sclerogastric cancer cells OCUM-2MD3 and OCUM-8, and induces apoptosis. Ki 23057 exhibits antitumor efficacy in mouse models[1].
Molecular Weight:
501.62
CAS Number:
[516523-31-2]
Formula:
C30H35N3O4
Target:
Apoptosis
Application Notes:
MCE Product type: Reference compound
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