COX-2/HDAC6-IN-1 (Compound 11e) is a dual COX-2 and HDAC6 inhibitor, with an IC50 of 0.12 µM against HDAC6 and an IC50 of 0.66 µM against COX-2. COX-2/HDAC6-IN-1 enhances the acetylation level of alpha-tubulin, regulates epigenetic gene expression, and inhibits the expression of pro-inflammatory mediators (COX-2, IL-1beta, IL-6 and TNF-alpha). COX-2/HDAC6-IN-1 promotes Amyloid-beta clearance and reduces excessive phosphorylation of Tau protein. COX-2/HDAC6-IN-1 maintains neuronal morphology by stabilizing MAP2, protects synaptic integrity by regulating synapsin, and restores the expression of memory-related genes. COX-2/HDAC6-IN-1 possesses neuroprotective activity and improves learning and memory abilities in Scopolamine (HY-N0296)-induced Alzheimers disease mouse models. COX-2/HDAC6-IN-1 is applicable to research related to Alzheimers disease[1].
Molecular Weight:
487.53
Formula:
C23H25N3O7S
Target:
Amyloid-beta,COX,HDAC,Interleukin Related,Microtubule/Tubulin,Tau Protein
Application Notes:
MCE Product type: Reference compound
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