RIPK1-IN-40 (Compound 51) is a RIPK1 inhibitor and anti-necroptotic agent (with an EC50 of 0.07 µM against necroptosis). RIPK1-IN-40 binds to the kinase domain of RIPK1, forms hydrogen bond interactions with Met95, and establishes additional polar contacts with Asp156 to stabilize binding, thereby inhibiting necroptosis. RIPK1-IN-40 can be used for the research of colorectal cancer[1].
Molecular Weight:
559.51
Formula:
C27H18F5N3O3S
Target:
Necroptosis,RIP kinase
Application Notes:
MCE Product type: Reference compound
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