RPI-GLYT2-82 is a reversible, blood-brain barrier-permeable allosteric inhibitor of GlyT2 with an IC50 value of 554 nM. RPI-GLYT2-82 also exhibits inhibitory activity against 5-HT2AR and SERT, with IC50 values of 1.9 µM and 4.7 µM, respectively. RPI-GLYT2-82 inhibits pain signals and alleviates allodynia, shows no target-related side effects at the maximum analgesic dose, and has no addictive potential. RPI-GLYT2-82 can be used for the research of neuropathic pain[1].
Molecular Weight:
443.97
Formula:
C24H30ClN3O3
Target:
5-HT Receptor,GlyT,Serotonin Transporter
Application Notes:
MCE Product type: Reference compound
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