GIT1-IN-1 is an inhibitor of ARF GTPase-activating protein 1 (GIT1) with a KD of 6.2 µM. GIT1-IN-1 induces apoptosis (apoptosis) in liver and colon cancer cells, arrests the cell cycle at the G2/M phase, and inhibits cell proliferation, colony formation and migration. GIT1-IN-1 inhibits the activities of MEK and ERK, reduces the expression level of cyclin D1, and stabilizes cyclin B1 protein in liver and colon cancer cells. GIT1-IN-1 can be used in the research of liver cancer and colon cancer[1].
Molecular Weight:
424.47
CAS Number:
[844464-54-6]
Formula:
C21H20N4O4S
Target:
Apoptosis,CDK,ERK,MEK,Ras
Application Notes:
MCE Product type: Reference compound
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