HJ03 is a blood-brain barrier-permeable, orally active DNA damage and ferroptosis inducer. HJ03 triggers ferroptosis by increasing intracellular ROS, Fe2+ accumulation and lipid peroxidation. HJ03 induces DNA adducts and interstrand crosslinks, blocks DNA replication and transcription, arrests cells at the G2/M phase and induces apoptosis. HJ03 can be used in the research of glioblastoma multiforme and colorectal cancer[1].
Molecular Weight:
482.75
CAS Number:
[3028123-48-7]
Formula:
C16H22Cl3N7O4
Target:
Apoptosis,DNA Alkylator/Crosslinker,DNA/RNA Synthesis,Ferroptosis,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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