VPC285785 is an orally active SARS-CoV-2 main protease inhibitor with an IC50 of 0.8 µM and a Kd of 2.7 µM. VPC285785 functionally inhibits the viral main protease-mediated processing of viral polyprotein precursors required for viral replication. VPC285785 reduces viral loads in the liver, brain and spleen tissues of MHV-infected mice. VPC285785 is applicable to the research of coronavirus infections[1].
Molecular Weight:
469.48
CAS Number:
[2759276-10-1]
Formula:
C24H25F2N5O3
Target:
SARS-CoV
Application Notes:
MCE Product type: Reference compound
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