IRBM-Z-1 is a non-competitive inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC50 of 1.8 µM. IRBM-Z-1 also exhibits inhibitory activity against the NS2B-NS3 proteases of T156I-mutated dengue virus 2 (DENV2) and West Nile virus (WNV), with IC50 values of 3.9 µM and 4.7 µM, respectively. IRBM-Z-1 inhibits ZIKV replication, attenuates virus-induced cytopathic effects. IRBM-Z-1 is applicable to research related to ZIKV infection[1].
Molecular Weight:
390.36
CAS Number:
[67629-86-1]
Formula:
C19H17F3N4O2
Target:
Flavivirus,Virus Protease
Application Notes:
MCE Product type: Reference compound
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