IRBM-Z-2 is a non-competitive, orally active Zika virus (ZIKV) NS2B-NS3 protease inhibitor, with IC50 values of 0.04 µM and 3.1 µM against the wild-type and I156T mutant strains, respectively. IRBM-Z-2 exhibits broad-spectrum anti-flavivirus potential, with IC50 values of 2.1 µM and 0.09 µM against the NS2B-NS3 proteases of dengue virus 2 (DENV2) and West Nile virus (WNV), respectively. IRBM-Z-1 inhibits ZIKV replication and alleviates virus-induced cytopathic effects. IRBM-Z-1 can be used in studies related to ZIKV infection[1].
Molecular Weight:
469.42
CAS Number:
[3014840-61-7]
Formula:
C22H18F3N7O2
Target:
Flavivirus,Virus Protease
Application Notes:
MCE Product type: Reference compound
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