EGFR/VEGFR2-IN-12 (compound 11a) is a dual EGFR/VEGFR2 inhibitor, with an IC50 value of 64 nM against human EGFR and an IC50 value of 74 nM against human VEGFR2. EGFR/VEGFR2-IN-12 inhibits the phosphorylation of EGFR and VEGFR2, induces cell cycle arrest at the G1/S phase, activates apoptotic pathways, promotes PARP-1 cleavage, exhibits low micromolar antiproliferative activity, and shows much higher selectivity for cancer cells than normal cells. EGFR/VEGFR2-IN-12 is applicable for cancer-related research[1].
Molecular Weight:
552.04
Formula:
C31H22ClN3O3S
Target:
EGFR,VEGFR
Application Notes:
MCE Product type: Reference compound
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