17beta-HSD10-IN-4 is a selective brain-penetrant 17beta-HSD10 inhibitor with an IC50 of 6.33 µM. 17beta-HSD10-IN-4 forms key interactions with the 17beta-HSD10 catalytic triad to functionally inhibit the enzyme, without altering its protein levels. 17beta-HSD10-IN-4 restores mitochondrial function, reduces ROS levels, increases ATP production, and suppresses cytochrome c release. 17beta-HSD10-IN-4 attenuates CDK5/p25 activation, reduces Tau hyperphosphorylation, Abeta plaque load and restores brain-derived neurotrophic factor levels. 17beta-HSD10-IN-4 improves cognitive function.17beta-HSD10-IN-4 can be used for the research of Alzheimers disease[1].
Molecular Weight:
288.32
Formula:
C14H12N2O3S
Target:
17beta-HSD,Amyloid-beta,CDK,Mitochondrial Metabolism,Reactive Oxygen Species (ROS),Tau Protein
Application Notes:
MCE Product type: Reference compound
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