Nrf2 activator-24 is a Nrf2 activator with anti-inflammatory and antioxidant activities. Nrf2 activator-24 promotes the nuclear translocation of Nrf2, thereby inducing the expression of downstream antioxidant and cytoprotective genes. Nrf2 activator-24 inhibits cytokine-driven inflammatory responses in keratinocytes. Nrf2 activator-24 attenuates inflammation, nitrosation and oxidative stress responses in macrophages. Nrf2 activator-24 alleviates local inflammation and atopic dermatitis-like symptoms in DNCB-induced mouse models. Nrf2 activator-24 can be used in research related to atopic dermatitis[1].
Molecular Weight:
360.09
Formula:
C14H10Cl2O2Se
Target:
Heme Oxygenase (HO),Interleukin Related,NF-kappaB,NO Synthase,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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