DENV-IN-15 is a sulfonyl anthranilic acid derivative and a pan-serotype anti-dengue virus (DENV) inhibitor with broad-spectrum anti-RNA virus activity. The EC50 value of DENV-IN-15 against DENV-2 in Huh-7 cells is 0.7 µM. DENV-IN-15 selectively regulates the translation of mRNAs encoding translation-related proteins and containing a 5-oligopyrimidine tract. DENV-IN-15 reduces the expression of specific ribosomal proteins, thereby inhibiting viral replication. DENV-IN-15 exhibits enhanced membrane permeability, human plasma stability and human liver microsomal metabolic stability. DENV-IN-15 is applicable to research related to dengue virus infection[1].
Molecular Weight:
506.66
Formula:
C28H34N4O3S
Target:
Dengue Virus
Application Notes:
MCE Product type: Reference compound
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