PDE4B/D-IN-5, CAS [[3064814-26-9]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-182060
Supplier Catalog Number:
HY-182060
Alternative Catalog Number:
MCE-HY-182060-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
PDE4B/D-IN-5 (Compound P32) is a peripherally restricted, oral active inhibitor of PDE4B and PDE4D with extremely low blood-brain barrier penetration, with IC50 values of 3.4 nM and 2.2 nM, respectively. PDE4B-IN-8 inhibits the production of TNF-alpha. PDE4B/D-IN-5 significantly reduces the Bax/Bcl2 ratio, and alleviates oxidative stress by decreasing MPO activity and NO levels. PDE4B/D-IN-5 exhibits anti-inflammatory, antioxidant, and anti-apoptotic activities. PDE4B/D-IN-5 can be used for the research of acute lung injury[1].
