GPX4-IN-23 (Compound 3e) is a GPX4 inhibitor with an IC50 of 0.27 µM. GPX4-IN-23 induces Ferroptosis by enhancing lipid peroxidation, ROS production, and intracellular GSH depletion. GPX4-IN-23 exhibits antiproliferative activity against central nervous system cancer cells. GPX4-IN-23 can be used in studies related to central nervous system cancers[1].
Molecular Weight:
399.49
Formula:
C24H25N5O
Target:
Ferroptosis,Glutathione Peroxidase,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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