CGS 35601 is the inhibitor for endothelin-converting enzyme-1 (ECE-1), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme (ACE), with IC50s of 55, 2, and 22 nM, respectively. CGS 35601 suppresses the big endothelin-1 (big ET-1)- and angiotensin I-induced pressor response, and enhances circulation of atrial natriuretic peptide (ANP), regulates the cardiovascular function in SD rats[1].
Molecular Weight:
445.58
CAS Number:
[849066-09-7]
Formula:
C23H31N3O4S
Target:
Angiotensin-converting Enzyme (ACE)
Application Notes:
MCE Product type: Reference compound
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