PDL1 degrader-3, CAS [[2488699-00-7]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-182239
Supplier Catalog Number:
HY-182239
Alternative Catalog Number:
MCE-HY-182239-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
PDL1 degrader-3 (comppund e24) is a CSN5-binding antitumor immunomodulator with a human CSN5 Kd of 4.53 µM. PDL1 degrader-3 inhibits CSN5 enzymatic activity, increases PD-L1 ubiquitination, and induces PD-L1 degradation via the ubiquitin-proteasome pathway, reducing PD-L1 expression on tumor cell membranes. PDL1 degrader-3 blocks PD-1/PD-L1 interaction, activates the tumor immune microenvironment, enhances tumor-infiltrating T-cell immunity, and inhibits activation of immunosuppressive MDSCs and Tregs. PDL1 degrader-3 exerts antitumor effects in mouse tumor models. PDL1 degrader-3 can be used for the research of colorectal cancer, lung cancer[1].
Molecular Weight:
264.28
CAS Number:
[2488699-00-7]
Formula:
C16H12N2O2
Target:
PD-1/PD-L1
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
