MC2050 is a selective PARP-1 inhibitor with an IC50 of 119 nM. MC2050 functionally inhibits PARP-1 activity, including hyperactivation induced by oxidative stress, and reduces the poly (ADP-ribosyl) ation level of histone H1. MC2050 protects neuroblastoma cells from oxidative stress-mediated cell death induced by hydrogen peroxide. MC2050 is applicable to research related to neuroblastoma and Burkitt lymphoma[1].
Molecular Weight:
440.39
CAS Number:
[1301757-19-6]
Formula:
C19H23Cl2N5OS
Target:
PARP
Application Notes:
MCE Product type: Reference compound
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