D-473 is an orally active, blood-brain barrier penetrant and serotonin-preferring reuptake inhibitor. D-473 inhibits serotonin, dopamine and norepinephrine transporters, and significantly elevates the extracellular levels of these three neurotransmitters in rat brain regions. D-473 exhibits definite antidepressant-like activity without inducing motor activation. D-473 is widely used in studies related to major depressive disorder[1].
Molecular Weight:
439.49
CAS Number:
[1632000-05-5]
Formula:
C26H27F2NO3
Target:
Dopamine Transporter,Serotonin Transporter
Application Notes:
MCE Product type: Reference compound
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