Antibiofilm agent-21 is an orally active prodrug of Antibiofilm agent-20 (HY-182268) with glucuronidation. Antibiofilm agent-21 avoids absorption in the small intestine via reduced membrane permeability, improving colon delivery rate, and converts to its active form in the colon. Antibiofilm agent-21 increases colon length and reduces IL-17 and TNF-alpha levels in a murine DSS (HY-116282C)-induced colitis model. Antibiofilm agent-21 can be used for the research of inflammatory bowel disease[1].
Molecular Weight:
567.67
Formula:
C31H41N3O7
Target:
Bacterial,Interleukin Related,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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