FOXM1-IN-4 (compound36) hydrochloride acts as a 5-HT7 receptor antagonist and FOXM1 modulator, with a Ki of 92 nM against the 5-HT7 receptor and high selectivity over 5-HT1A, 5-HT2A and 5-HT6 receptors. FOXM1-IN-4 (hydrochloride) blocks the 5-HT7 receptor signaling pathway, reduces the levels of total FOXM1 protein and phosphorylated FOXM1 protein, and downregulates the expression of cyclin B1 and cdc25B. FOXM1-IN-4 (hydrochloride) induces cell cycle arrest at the G2/M phase, decreases the proportion of cells in the G0/G1 phase, and inhibits clonogenic capacity. FOXM1-IN-4 (hydrochloride) suppresses cancer cell proliferation and is applicable to research related to triple-negative breast cancer[1].
Molecular Weight:
493.05
Formula:
C26H33ClN8
Target:
5-HT Receptor,DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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