OH14 is a cellular FLICE-like inhibitory protein (cFLIP) inhibitor and TNF-related apoptosis-inducing ligand (TRAIL) sensitizer. OH14 selectively binds to the DED1 pocket of cFLIP, disrupting its recruitment to the TRAIL-death inducing signalling complex without affecting procaspase-8 recruitment to FADD, allowing procaspase-8 activation. OH14 promotes TRAIL-mediated apoptosis and impairs cell viability in breast cancer systems when combined with TRAIL. OH14 can be used for the research of breast cancer[1].
Molecular Weight:
360.21
CAS Number:
[1018153-87-1]
Formula:
C14H11Cl2NO4S
Target:
Apoptosis,Caspase,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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