CTX-439 is an orally active, ATP-competitive small-molecule inhibitor of CDK12 and CDK13, with an IC50 of 3.1 nM and a Kd of 0.38 nM against CDK12, and an IC50 of 9.2 nM against CDK13. CTX-439 induces DNA damage and apoptosis in tumor cells. CTX-439 is applicable for the research of breast cancer and ovarian cancer[1].
Molecular Weight:
671.69
CAS Number:
[2377487-13-1]
Formula:
C30H32F3N9O4S
Target:
Apoptosis,CDK
Application Notes:
MCE Product type: Reference compound
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