WRN-IN-25 is an allosteric Werner syndrome helicase (WRN) inhibitor with an IC50 of 15 nM and a Kd of 54 nM. WRN-IN-25 induces DNA damage, reduces cell viability, and exhibits synthetic lethality in WRN-driven high microsatellite instability cancer cells. WRN-IN-25 can be used in research related to microsatellite instability cancers[1].
Molecular Weight:
592.68
Formula:
C33H38F2N4O4
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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