JAK3-IN-20, CAS [[3104109-31-8]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-182314
Supplier Catalog Number:
HY-182314
Alternative Catalog Number:
MCE-HY-182314-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
JAK3-IN-20 is a selective and orally active JAK3 inhibitor with an IC50 of 0.7473 nM. JAK3-IN-20 forms a covalent bond with JAK3 Cys909, outcompetes ATP for catalytic site binding, and blocks JAK-STAT pathway activation. JAK3-IN-20 inhibits migration, proliferation, and tumor growth of Bortezomib (HY-10227)-resistant cancer cells. JAK3-IN-20 induces dose-dependent apoptosis. JAK3-IN-20 can be used for the research of Bortezomib-resistant multiple myeloma[1].
Molecular Weight:
499.01
CAS Number:
[3104109-31-8]
Formula:
C24H31ClN8O2
Target:
Apoptosis,JAK,STAT
Application Notes:
MCE Product type: Reference compound
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