PF-07245303 is a ITK/TRK inhibitor. PF-07245303 reduces the production of inflammatory cytokines such as IL-4 and IFNgamma, and inhibits the phosphorylation of PLCgamma1. PF-07245303 inhibits nerve growth factor-induced basophil activation and the phosphorylation of TRKA. PF-07245303 reduces oxazolone-induced ear swelling in mouse ear tissues. PF-07245303 is applicable to research related to atopic dermatitis[1].
Molecular Weight:
448.56
CAS Number:
[2655556-75-3]
Formula:
C25H32N6O2
Target:
IFNAR,Interleukin Related,Itk,Trk Receptor
Application Notes:
MCE Product type: Reference compound
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