PI3Kalpha-IN-30 is an orally active, selective PI3Kalpha inhibitor with an IC50 of 2.8 nM. PI3Kalpha-IN-30 inhibits cancer cell proliferation, as well as the phosphorylation of Akt (S473) and pS6 (S240/244). PI3Kalpha-IN-30 shows low growth inhibitory activity against normal somatic cell lines at a concentration of 30 µM. PI3Kalpha-IN-30 induces cancer cell apoptosis and exerts anti-tumor efficacy in xenograft models. PI3Kalpha-IN-30 can be used for the research of breast cancer[1].
Molecular Weight:
575.61
Formula:
C26H28F3N7O3S
Target:
Akt,Apoptosis,PI3K
Application Notes:
MCE Product type: Reference compound1
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