TKP-5 is a PROTAC protein degrader targeting BRD4. TKP-5 can binds to BRD2, BRD3, BRD4 and BRDT, with Ka values of 150 nM, 100 nM and 150 nM for the first three proteins respectively. TKP-5 inhibits the production of thymic stromal lymphopoietin and suppresses the expression of IL-33 mRNA. TKP-5 is applicable to studies related to tape-stripping induced skin injury[1].
Molecular Weight:
833.88
CAS Number:
[3076612-97-7]
Formula:
C44H47N7O10
Target:
Epigenetic Reader Domain,PROTACs
Application Notes:
MCE Product type: Reference compound1
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