DT-5461 is an IL-1 and TNF-alpha antagonist. DT-5461 competitively binds lipid A-binding sites on macrophage receptors, blocks LPS (HY-D1056)-initiated signaling, inhibits LPS-induced cytokine release, prevents LPS-induced serum cytokine production in mice, and protects against LPS-induced lethal endotoxemia. DT-5461 can be used for the research of lethal endotoxemia, medullary tubular mammary carcinoma, poorly differentiated colon adenocarcinoma, squamous-cell lung carcinoma, and gelatinous gastric adenocarcinoma[1][2][3].
Molecular Weight:
1449.82
CAS Number:
[123598-19-6]
Formula:
C73H133N4O22P
Target:
Interleukin Related,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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