ODZ10117 is a STAT3 and NLRP3 inhibitor with a human STAT3 SH2 domain IC50 of 7.5 µM. ODZ10117 binds to the STAT3 SH2 domain, suppressing tyrosine phosphorylation, dimerization, nuclear translocation, and transcriptional activity. ODZ10117 binds to NLRP3, impairs NEK7 interaction, prevents inflammasome formation, and inhibits caspase-1 and IL-1beta cleavage.ODZ10117 reduces MSU (HY-B2130A)-induced IL-1beta release, lowers LPS (HY-D1056)-induced sepsis mortality, and exhibits anti-inflammatory effects. ODZ10117 induces apoptosis. ODZ10117 can be used for the research of Monosodium urate (HY-B2130A)-induced peritonitis, LPS-induced sepsis, breast cancer, glioblastoma, and Alzheimers disease[1][2][3][4].
Molecular Weight:
362.42
CAS Number:
[1632152-27-2]
Formula:
C10H5Cl5N2O2
Target:
NOD-like Receptor (NLR),STAT
Application Notes:
MCE Product type: Reference compound
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