Triflocin is an orally active diuretic and Na+-K+-2Cl- cotransporter inhibitor with an IC50 of 3*10-5 M. Triflocin inhibits the outward basolateral electrogenic Na-(HCO3) n>1 cotransport in the proximal tubule. Triflocin has no tendency to induce hyperglycemia, and its blood glucose-elevating effect is extremely weak, such that an increase in blood glucose levels can only be detected under special conditions such as glucose loading. Triflocin is more prone to induce hypoglycemia[1][2].
Molecular Weight:
282.22
CAS Number:
[13422-16-7]
Formula:
C13H9F3N2O2
Target:
NKCC
Application Notes:
MCE Product type: Reference compound
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