MKI-3 is a selective microtubule-associated serine/threonine kinase-like (MASTL) inhibitor with an IC50 of 5.72 nM and a Kd of 1.89 nM. MKI-3 disrupts the MASTL-ENSA-Aurora A signaling axis. MKI-3 induces chromosomal instability, mitotic catastrophe and apoptosis (apoptosis) in cancer cells. MKI-3 is applicable to research related to triple-negative breast cancer[1].
Molecular Weight:
385.42
CAS Number:
[3084702-28-0]
Formula:
C21H19N7O
Target:
Apoptosis,Aurora Kinase,Caspase,MASTL,PARP
Application Notes:
MCE Product type: Reference compound
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