DM-1157 is an orally active asymmetric bisquinoline heme inhibitor with a IC50 of 1.6 µM and a Kd of 1.7 µM. DM-1157 binds to heme dimers in solution, inhibits beta-hematin formation, suppresses hemozoin formation in the digestive vacuole of Plasmodium falciparum, accumulates in the digestive vacuole of Plasmodium falciparum, induces enlargement of the digestive vacuole of Plasmodium falciparum, and inhibits the growth of Chloroquine (HY-17589A)-sensitive and resistant Plasmodium falciparum strains. DM-1157 can be used for the research of malaria and Plasmodium falciparum-type malaria[1][2].
Molecular Weight:
487.04
CAS Number:
[1239953-66-2]
Formula:
C28H31ClN6
Target:
Parasite
Application Notes:
MCE Product type: Reference compound
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