GQ127 is an orally active Galphaq/11 inhibitor with an IC50 of 22.6 µM. GQ127 binds directly to Galphaq/11 protein and inhibits its activity. GQ127 induces Apoptosis, suppresses viability, migration and invasion of uveal melanoma cells. GQ127 increases the phosphorylation level of YAP and decreases the phosphorylation level of ERK. GQ127 inhibits the growth of uveal melanoma xenografts in mouse models. GQ127 can be used for research related to uveal melanoma[1].
Molecular Weight:
408.58
CAS Number:
[2625582-70-7]
Formula:
C25H36N4O
Target:
Apoptosis,ERK,YAP
Application Notes:
MCE Product type: Reference compound
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